Arnau Women Research Group

Strategic Lines

These are the research lines in which members of the Arnau Dona research group have participated over the past five years. Their work covers a wide range of clinical studies in gynecology, obstetrics, and reproductive health.

Minimally Invasive Endoscopic Surgery (Gynecological Laparoscopy):

• Effectiveness and safety of salpingectomy with minicornucetomy for Essure device removal.
• Retrospective studies on symptom evolution after Essure explantation.
• Frequency of nerve injury in lateral trocar placement.
• Long-term impact of abdominal myomectomy on reproductive outcomes.
• Comparative analysis of robotic-assisted vs. conventional laparoscopic hysterectomy.
• Advantages of robotic pelvic surgery in reducing abdominal scars for deep endometriosis.

Endoscopic Approach to Uterine Pathology (Hysteroscopy):

• Use of virtual reality to reduce anxiety and pain during outpatient hysteroscopy.
• Ultrasound estimation of retained material volume in hysteroscopic treatment.
• Hystero-embryoscopy for diagnosing recurrent first-trimester miscarriage.
• OPPIUM technique for preparing type 2 fibroids for surgical removal.
• Safety and effectiveness of hysteroscopic morcellation for retained products.
• Prediction of Lasmar classification via gynecological ultrasound.
• Estimation of blood loss during hysteroscopic myomectomy.

Reproductive Medicine:

• Tubal patency assessment using hysterosonosalpingography and its relation to Chlamydia infection.
• Chlamydia trachomatis as a risk factor for infertility.
• Development of clinical protocols for assisted reproduction in Catalonia.
• Multicenter trial on contraceptive efficacy and safety of dienogest/ethinyl estradiol.

Endometriosis:

• Molecular and phenotypic complexity of endometriosis using omics and new models.
• Personalized medicine approaches and biomarker validation for diagnosis and recurrence prediction.
• Detection of molecular biomarkers in menstrual blood, saliva, and venous blood.
• Comparative molecular studies of endometrium in patients with and without endometriosis.

Gynecological Ultrasound:

• Elastography parameters in normal and pathological myometrium.
• Differentiation between myoma and adenomyoma using ultrasound.
• Correlation of preoperative ultrasound findings with surgical and MRI results in deep endometriosis.

Gynecological Cancer:

• Role of ARID1A in endometrial carcinogenesis and therapeutic implications.
• Rapid detection of lymph node metastasis in cervical and endometrial cancer using OSNA.
• Use of Glubran 2® to reduce seroma in axillary lymphadenectomy.
• Utility of 2D/3D ultrasound in preoperative staging of endometrial and cervical cancer.
• Liquid biopsy strategies for risk evaluation and personalized therapy in endometrial cancer.
• Multicenter studies on diagnostic indices for pelvic adnexal tumors.

Pelvic Floor Pathology:

• Use of acellular dermal matrix and ligament fixation for prolapse treatment.
• Long-term follow-up and management of obstetric anal sphincter injuries.

High-Risk Pregnancy - Placental Pathology:

• Screening for preeclampsia in twin pregnancies.
• Management of early-onset fetal growth restriction using angiogenic factors and Doppler.
• Incorporation of sFlt1/PlGF ratio in preeclampsia diagnosis.

High-Risk Pregnancy - Maternal Pathology:

• Retinal microvasculature angiography in healthy and diabetic pregnant women.
• Outcomes in pregnancies of advanced maternal age.
• Randomized trials to reduce cesarean rates in obese pregnant women.
• Outcomes following myomectomy.

Childbirth Care:

• National studies on induction methods and maternal/perinatal morbidity and mortality.
• Effectiveness and safety of double balloon cervical induction.
• Participation in Spanish registry of maternal and perinatal morbidity.