ILERVAS - El Bus de la Salut: Connecting science and health
Group leader
Strategic Lines
Main activities and timeline of the Translational Research Program
Description of the research lines, specific scientific and training tasks, and specific actions to promote the visibility of the Program. Also, include the schedule of the future actions of the Program for the next 3 years.
RESEARCH LINES
Precision Risk Stratification and Prediction
- Development of sex-specific algorithms for atherosclerosis and cardiovascular event prediction.
- Vascular ultrasound-based quantification of atheroma burden for cardiovascular risk stratification.
- Assessment of the ankle-brachial index as a population screening tool.
- Integration of exposome data (environmental, behavioural, and occupational exposures) into risk prediction.
Pathophysiological Mechanisms and Biomarkers
- Discovery of circulating and molecular biomarkers of atherosclerosis progression.
- Role of oxidative stress, metabolism, and advanced glycation end-products (AGEs, measured by skin autofluorescence) in vascular injury.
- Impact of metabolic and redox changes during ageing and neurodegeneration.
- Mechanistic studies on hidden kidney disease and its link to atherosclerosis and hypertension.
Metabolic and Lifestyle Determinants
- Influence of Mediterranean diet and physical exercise on cardiovascular and metabolic health.
- Relationship between smoking and the burden of cardiovascular disease.
- Characterization of body composition using anthropometric and mathematical models.
- Study of prediabetes, diabetes, and metabolic syndrome in the development of subclinical atheromatosis.
Sleep and Chronobiology in Cardiovascular Disease
- Analysis of the interaction between diabetes and respiratory function.
- Impact of sleep-disordered breathing and nocturnal hypoxia on cardiovascular outcomes.
- Chronobiology of vascular and metabolic regulation.
Population Epidemiology and Health Implementation
- Applied epidemiology in the study of chronic and communicable diseases in primary care.
- Translation of population-based findings into preventive and clinical strategies.
